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CS-W001157 4
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4-Aminopicolinic acid

  • CAS No. 100047-36-7

  • Cat. No. CS-0033962
  • Purity≥97%
  • MDL No.MFCD02685671

*For research and further manufacturing use only, not for direct human use.

4-Aminopicolinic acid|CS-0033962

Structure of 100047-36-7

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General Information

  • CAS No. 100047-36-7
  • Cat. No. CS-0033962
  • Purity ≥97%
  • MDL No. MFCD02685671
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₂
  • Molecular Weight 138.12
  • Synonym(s) Picolinic acid, 4-amino-
  • SMILES O=C(C1=NC=CC(N)=C1)O

Application

4-Aminopicolinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyridine-based scaffolds through standard coupling and cyclization reactions. Its ortho-carboxylic acid and para-amino groups provide complementary reactivity for amide formation, metal-catalyzed cross-coupling, and heterocycle construction. Bench-stable and readily purified, it functions effectively in peptide-like derivatization and transition metal-mediated transformations.

Synthesis

  • Route1

    References

    • UNIVERSITE DE MONTREAL; RUEL, Rejean; CHANTIGNY, Yves; MARINIER, Anne; RENE, Patricia; BOUVIER, Michel Patent: WO2012/3576 A1, 2012 ; Location in patent: Page/Page column 96 ; WO 2012/003576 A1
  • Route2
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    • In-stock
      4-Aminopicolinic acid|CS-0033962
      100047-36-7

    References

    • US5444057 A1, ;
  • Route3

    References

    • Australian Journal of Chemistry, , vol. 35, # 10 p. 2025 - 2034

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   76.21
  • LogP   0.362
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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