Fmoc-His(Fmoc)-OH

Name: Fmoc-His(Fmoc)-OH
Brand: ChemScene
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CAS No. 98929-98-7
Cat. No. CS-W013799
Molecule weight599.63
Purity≥95%
MDL No.MFCD00070658

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 98929-98-7
Cat. No. CS-W013799
Purity ≥95%
MDL No. MFCD00070658
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₆H₂₉N₃O₆
Molecular Weight 599.63
Synonym(s) None
SMILES O=C(O)[C@@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)CC4=CN(C(OCC5C6=CC=CC=C6C7=CC=CC=C75)=O)C=N4

Description

Fmoc-His(Fmoc)-OH is a protected histidine derivative featuring two Fmoc groups, enabling efficient incorporation into solid-phase peptide synthesis. The dual protection ensures selective coupling at the imidazole nitrogen while preserving the α-amino group for chain elongation. This variant offers enhanced solubility and stability under standard coupling conditions, streamlining synthesis of complex peptides containing modified histidine residues.

Application

Fmoc-His(Fmoc)-OH serves as a doubly protected histidine derivative for solid-phase peptide synthesis, enabling efficient incorporation of histidine residues with orthogonal protection. The Fmoc group on the α-amino function allows for base-labile removal, while the side-chain imidazole is preserved in its protected form, facilitating selective deprotection and subsequent functionalization. Its stability under standard coupling conditions and compatibility with diverse amino acid sequences make it a reliable building block for peptide library synthesis and targeted biomolecule construction.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P330-P405-P501

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Computational Chemistry Data

TPSA 119.75
LogP 6.2147
H_Acceptors 7
H_Donors 2
Rotatable_Bonds 8

Other Classifications

Bioactive Molecules Peptides

Building Blocks Functional Group Fmoc

Life Science Amino Acids and their Derivatives Histidine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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Fmoc-His(Fmoc)-OH

CAS No. 98929-98-7

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