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CS-W001157 4
Total: USD 88.00

Boc-His(Trt)-OH

  • CAS No. 32926-43-5

  • Cat. No. CS-W011504
  • Purity≥98%
  • MDL No.MFCD00153307

*For research and further manufacturing use only, not for direct human use.

Boc-His(Trt)-OH|CS-W011504

Structure of 32926-43-5

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General Information

  • CAS No. 32926-43-5
  • Cat. No. CS-W011504
  • Purity ≥98%
  • MDL No. MFCD00153307
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₀H₃₁N₃O₄
  • Molecular Weight 497.58
  • Synonym(s) None
  • SMILES OC([C@@H](NC(OC(C)(C)C)=O)CC1=CN(C=N1)C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=O

Description

Boc-His(Trt)-OH is a protected histidine derivative featuring orthogonal side-chain and α-amino protection. The Trt group stabilizes the imidazole nitrogen, while the Boc moiety prevents racemization during peptide coupling. This dual-protected form simplifies incorporation into synthetic peptides under standard conditions, offering enhanced stability and ease of handling in solid-phase synthesis workflows.

Synthesis

  • Route1
    • N-[(1,1-Dimethylethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine methyl ester|CS-0525095
      62697-87-4
    • ~83%
    • In-stock
      Boc-His(Trt)-OH|CS-W011504
      32926-43-5

    References

    • Boger, Dale L.; Teramoto, Shuji; Cai, Hui Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 179 - 193
  • Route2

    References

    • Pozdnev, V. F. Chemistry of Natural Compounds, 1982 , vol. 18, # 3 p. 322 - 327 Khimiya Prirodnykh Soedinenii, 1982 , # 3 p. 349 - 354
  • Route3
    • null|null
      76-83-5
    • ~%
    • In-stock
      Boc-His(Trt)-OH|CS-W011504
      32926-43-5

    References

    • Bioorganic and Medicinal Chemistry, , vol. 4, # 2 p. 179 - 193

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   93.45
  • LogP   5.2437
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   8

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