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CS-W001157 4
Total: USD 88.00

H-His(Trt)-OH

  • CAS No. 35146-32-8

  • Cat. No. CS-W013871
  • Purity≥95%
  • MDL No.MFCD00153444

*For research and further manufacturing use only, not for direct human use.

H-His(Trt)-OH|CS-W013871

Structure of 35146-32-8

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General Information

  • CAS No. 35146-32-8
  • Cat. No. CS-W013871
  • Purity ≥95%
  • MDL No. MFCD00153444
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₂₃N₃O₂
  • Molecular Weight 397.48
  • Synonym(s) None
  • SMILES OC([C@@H](N)CC1=CN(C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C=N1)=O

Description

H-His(Trt)-OH is a protected histidine derivative featuring a trifluoroacetyl group at the N-terminal amine and a hydroxyl side chain. This configuration enables direct incorporation into peptide sequences under standard coupling conditions, offering improved solubility and reduced racemization during synthesis. The Trt protection remains stable through multiple reaction steps while allowing selective deprotection when required.

Synthesis

  • Route1

    References

    • WO2012/136604 A1, ; Page/Page column 42-43 ;
  • Route2

    References

    • Chemistry of Natural Compounds, , vol. 18, # 3 p. 322 - 327 Khimiya Prirodnykh Soedinenii, , # 3 p. 349 - 354
  • Route3
    • Trt-his(trt)-oh|CS-0591533
      74853-62-6
    • ~%
    • In-stock
      H-His(Trt)-OH|CS-W013871
      35146-32-8

    References

    • Chemistry of Natural Compounds, , vol. 18, # 3 p. 322 - 327 Khimiya Prirodnykh Soedinenii, , # 3 p. 349 - 354

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   81.14
  • LogP   3.6777
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   7

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