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CS-W001157 4
Total: USD 88.00

4-Bromo-5-ethyl-2-methylpyridine

  • CAS No. 98488-99-4

  • Cat. No. CS-0146041
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-5-ethyl-2-methylpyridine|CS-0146041

Structure of 98488-99-4

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General Information

  • CAS No. 98488-99-4
  • Cat. No. CS-0146041
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀BrN
  • Molecular Weight 200.08
  • Synonym(s) 5-ethyl-4-bromo-2-methyl-pyridine
  • SMILES CC1=NC=C(CC)C(Br)=C1

Description

4-Bromo-5-ethyl-2-methylpyridine is a halogenated pyridine derivative featuring complementary alkyl substituents that enhance reactivity in cross-coupling processes. The bromine atom enables efficient Pd-catalyzed transformations, while the ethyl and methyl groups provide steric and electronic tuning for selective functionalization. This compound serves as a key intermediate in medicinal chemistry and agrochemical synthesis.

Application

4-Bromo-5-ethyl-2-methylpyridine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-defined halogen reactivity. The ortho-methyl and ethyl substituents provide steric and electronic modulation, enhancing regioselectivity in downstream transformations. Its bench-stable nature and compatibility with standard purification protocols make it suitable for iterative synthesis of complex pyridine-based scaffolds in medicinal chemistry and agrochemical research.

Synthesis

  • Route1
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      1131-20-0
    • ~%
    • In-stock
      4-Bromo-5-ethyl-2-methylpyridine|CS-0146041
      98488-99-4

    References

    • Prasad; Swan Journal of the Chemical Society, 1958 , p. 2024,2034 Full Text Show Details Lee; Swan Journal of the Chemical Society, 1956 , p. 771,774
  • Route2
    • null|null
      768-44-5
    • ~%
    • In-stock
      4-Bromo-5-ethyl-2-methylpyridine|CS-0146041
      98488-99-4

    References

    • Lee; Swan Journal of the Chemical Society, 1956 , p. 771,774

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.71492
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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