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CS-W001157 4
Total: USD 88.00

3-Bromo-6-methoxypicolinonitrile

  • CAS No. 1186637-43-3

  • Cat. No. CS-0131933
  • Purity≥98%
  • MDL No.MFCD08062835
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-methoxypicolinonitrile|CS-0131933

Structure of 1186637-43-3

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Description

3-Bromo-6-methoxypicolinonitrile features a pyridine core functionalized with bromine, methoxy, and nitrile groups, enabling diverse coupling reactions. The electron-deficient ring facilitates nucleophilic substitution, while the methoxy group enhances solubility and modulates reactivity. This compound serves as a key intermediate in synthesizing bioactive heterocycles and pharmaceutical scaffolds under standard conditions.

Application

3-Bromo-6-methoxypicolinonitrile serves as a versatile building block for heterocyclic synthesis, enabling efficient access to substituted pyridine scaffolds via palladium-catalyzed cross-coupling reactions. The bromo group facilitates C–C bond formation under standard Suzuki, Stille, or Negishi conditions, while the nitrile and methoxy functionalities offer orthogonal reactivity for downstream transformations. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for medicinal chemistry and process development workflows.

General Information

  • CAS No. 1186637-43-3
  • Cat. No. CS-0131933
  • Purity ≥98%
  • MDL No. MFCD08062835
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrN₂O
  • Molecular Weight 213.03
  • Synonym(s) 3-Bromo-2-yyano-6-methoxypyridine
  • SMILES N#CC1=NC(OC)=CC=C1Br

Computational Chemistry Data

  • TPSA   45.91
  • LogP   1.72438
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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