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CS-W001157 4
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2-Methyl-2H-indazol-3-amine

  • CAS No. 97990-19-7

  • Cat. No. CS-0161402
  • Molecule weight147.18
  • Purity≥98%
  • MDL No.MFCD19205547

*For research and further manufacturing use only, not for direct human use.

2-Methyl-2H-indazol-3-amine|CS-0161402

Structure of 97990-19-7

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General Information

  • CAS No. 97990-19-7
  • Cat. No. CS-0161402
  • Purity ≥98%
  • MDL No. MFCD19205547
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉N₃
  • Molecular Weight 147.18
  • Synonym(s) 2H-Indazol-3-amine, 2-methyl-
  • SMILES NC1=C2C=CC=CC2=NN1C

Description

2-Methyl-2H-indazol-3-amine features a fused bicyclic core with a nitrogen-rich heterocyclic scaffold, offering enhanced solubility and stability in polar solvents. The methyl group at the 2-position imparts steric protection to the indazole ring, reducing undesired side reactions. This compound serves as a key building block for bioactive molecules in medicinal chemistry, particularly in kinase inhibitor development and targeted protein degradation scaffolds.

Application

2-Methyl-2H-indazol-3-amine serves as a versatile building block for medicinal chemistry, enabling the synthesis of indazole-based scaffolds through standard coupling reactions. Its stability under routine handling and compatibility with diverse functional groups facilitate efficient derivatization in API development workflows.

Synthesis

  • Route1
    • null|null
      137968-26-4
    • ~62%
    • In-stock
      2-Methyl-2H-indazol-3-amine|CS-0161402
      97990-19-7

    References

    • Salazar, Loreto; Espada, Modesta; Avendano, Carmen; Claramunt, Rosa Maria; Sanz, Dionisia; Elguero, Jose Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1563 - 1567
  • Route2
    • null|null
      97990-20-0
    • ~90%
    • In-stock
      2-Methyl-2H-indazol-3-amine|CS-0161402
      97990-19-7

    References

    • Quast, Helmut; Fuss, Andreas; Nahr, Uwe Chemische Berichte, 1985 , vol. 118, # 6 p. 2164 - 2185
  • Route3
    • null|null
      137968-11-7
    • ~%
    • In-stock
      2-Methyl-2H-indazol-3-amine|CS-0161402
      97990-19-7

    References

    • Salazar, Loreto; Espada, Modesta; Avendano, Carmen; Claramunt, Rosa Maria; Sanz, Dionisia; Elguero, Jose Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1563 - 1567

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   1.1555
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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