Lot numbers can be found on the outside label of a product:
1-Methyl-1H-indazol-3-amine
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CAS No. 60301-20-4
- Cat. No. CS-D1081
- Purity≥98%
- MDL No.MFCD09054755
*For research and further manufacturing use only, not for direct human use.
Structure of 60301-20-4
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General Information
- CAS No. 60301-20-4
- Cat. No. CS-D1081
- Purity ≥98%
- MDL No. MFCD09054755
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₉N₃
- Molecular Weight 147.18
- Synonym(s) 1-Methylindazol-3-amine
- SMILES NC1=NN(C)C2=C1C=CC=C2
Description
1-Methyl-1H-indazol-3-amine features a methylated indazolyl core with a primary amine at the 3-position, enabling direct functionalization in medicinal chemistry. This electron-rich heterocycle serves as a key scaffold for kinase inhibitors and bioactive molecules, offering improved metabolic stability and solubility compared to unsubstituted analogs.
Application
1-Methyl-1H-indazol-3-amine serves as a versatile building block in medicinal chemistry, enabling rapid access to bioactive heterocycles through standard coupling reactions. Its ortho-amino functionality facilitates direct derivatization, while the methyl group enhances metabolic stability and modulates solubility. The scaffold exhibits excellent bench stability, tolerates diverse functional groups, and is readily incorporated into kinase inhibitors and CNS-targeted compounds via amide bond formation or Suzuki couplings.
Synthesis
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Route1
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113385-39-0 - ~72%
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In-stock
60301-20-4
References
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AVEXA LIMITED Patent: WO2008/77188 A1, 2008 ; Location in patent: Page/Page column 131-132 ;
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Route2
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In-stock
365427-30-1 - ~%
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In-stock
60301-20-4
References
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US2012/245163 A1, ; Page/Page column 35 ; US 20120245163 A1
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Route3
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394-47-8
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60-34-4
- ~94%
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In-stock
60301-20-4
References
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Liu, Han-Jun; Hung, Shiang-Fu; Chen, Chuan-Lin; Lin, Mei-Huey Tetrahedron, 2013 , vol. 69, # 19 p. 3907 - 3912
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H317-H319
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Precautionary Statements : P261-P264-P272-P280-P302+P352-P362+P364-P501
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Quality Control
Computational Chemistry Data
- TPSA 43.84
- LogP 1.1555
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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