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CS-W001157 4
Total: USD 88.00

5-Chloro-2-fluorobenzaldehyde

  • CAS No. 96515-79-6

  • Cat. No. CS-W007736
  • Purity≥98%
  • MDL No.MFCD03094518

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-fluorobenzaldehyde|CS-W007736

Structure of 96515-79-6

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General Information

  • CAS No. 96515-79-6
  • Cat. No. CS-W007736
  • Purity ≥98%
  • MDL No. MFCD03094518
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClFO
  • Molecular Weight 158.56
  • Synonym(s) 3-pyridinecarbonyl chloride, 2,6-dichloro-5-fluoro-; 5-Chloro-2-fluorobenzaldehyde
  • SMILES O=CC1=CC(Cl)=CC=C1F

Description

5-Chloro-2-fluorobenzaldehyde features a fluorinated benzene ring bearing both chlorine and aldehyde functionalities, enabling selective electrophilic coupling in synthetic pathways. The electron-withdrawing halogens enhance reactivity at the aldehyde site while maintaining stability under standard conditions. This ortho-halogenated scaffold serves as a key intermediate for pharmaceuticals and agrochemicals.

Application

5-Chloro-2-fluorobenzaldehyde serves as a valuable building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of substituted heterocycles and biologically active scaffolds. Its ortho-halogenated benzaldehyde core facilitates direct electrophilic substitution, Suzuki-Miyaura coupling, and nucleophilic addition reactions under standard conditions. The compound exhibits good bench stability, ease of purification, and functional group tolerance, making it well-suited for multi-step synthesis workflows.

Synthesis

  • Route1
    • null|null
      352-33-0
    • null|null
      68-12-2
    • ~%
    • In-stock
      5-Chloro-2-fluorobenzaldehyde|CS-W007736
      96515-79-6

    References

    • US6350749 B1, ; Page column 136-137 ;
  • Route2
    • null|null
      768-66-1
    • null|null
      352-33-0
    • ~%
    • In-stock
      5-Chloro-2-fluorobenzaldehyde|CS-W007736
      96515-79-6

    References

    • EP950418 A2, ; EP 0950418 A2
  • Route3

    References

    • US5502073 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.2916
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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