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Structure of 959238-28-9
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1-Isopropylazetidine-3-carboxylic acid features a strained four-membered azetidine ring bearing a carboxylic acid at C3 and a sterically hindered isopropyl group at N1. This configuration imparts enhanced metabolic stability and favorable solubility, enabling efficient incorporation into bioactive molecules. The compound serves as a conformationally constrained building block for peptide mimetics and medicinal chemistry libraries.
1-Isopropylazetidine-3-carboxylic acid serves as a conformationally constrained, bioactive amino acid analog enabling the synthesis of peptidomimetics and heterocyclic scaffolds. Its azetidine core imparts enhanced metabolic stability and improved membrane permeability, while the isopropyl group provides steric bulk and modulates electronic properties. The carboxylic acid functionality facilitates direct coupling in solid-phase synthesis and supports derivatization via standard amide bond formation. This compound exhibits bench stability and tolerates diverse reaction conditions, making it a practical building block for medicinal chemistry campaigns targeting GPCRs and kinases.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: