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CS-W001157 4
Total: USD 88.00

1-Methylazetidine-3-carboxylic acid

  • CAS No. 875629-26-8

  • Cat. No. CS-W004004
  • Purity≥97%
  • MDL No.MFCD11520621

*For research and further manufacturing use only, not for direct human use.

1-Methylazetidine-3-carboxylic acid|CS-W004004

Structure of 875629-26-8

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General Information

  • CAS No. 875629-26-8
  • Cat. No. CS-W004004
  • Purity ≥97%
  • MDL No. MFCD11520621
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉NO₂
  • Molecular Weight 115.13
  • Synonym(s) 1-Methyl-3-azetidinecarboxylic acid
  • SMILES CN1CC(C1)C(=O)O

Description

1-Methylazetidine-3-carboxylic acid features a strained four-membered ring with a methylated nitrogen and a carboxylic acid group, enabling selective incorporation into peptides. This scaffold imparts conformational rigidity and enhanced metabolic stability, making it valuable for bioactive molecule design.

Application

1-Methylazetidine-3-carboxylic acid serves as a valuable scaffold in medicinal chemistry, offering a strained four-membered ring with enhanced metabolic stability. Its carboxylic acid functionality enables direct conjugation or derivatization, while the N-methyl group improves lipophilicity and membrane permeability. The compound exhibits good bench stability and facilitates efficient coupling reactions, making it a practical building block for peptide-like molecules and targeted API development.

Synthesis

  • Route1
    • null|null
      50-00-0
    • In-stock
      Azetidine-3-carboxylic acid|CS-W019846
      36476-78-5
    • ~93%
    • In-stock
      1-Methylazetidine-3-carboxylic acid|CS-W004004
      875629-26-8

    References

    • BOEHRINGER INGELHEIM INTERNATIONAL GMBH Patent: US2011/269737 A1, 2011 ; Location in patent: Page/Page column 44 ; US 20110269737 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.54
  • LogP   -0.3674
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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