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CS-W001157 4
Total: USD 88.00

2,4-Dichloro-8-fluoroquinazoline

  • CAS No. 959237-64-0

  • Cat. No. CS-W003702
  • Purity≥97%
  • MDL No.MFCD09954886

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-8-fluoroquinazoline|CS-W003702

Structure of 959237-64-0

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General Information

  • CAS No. 959237-64-0
  • Cat. No. CS-W003702
  • Purity ≥97%
  • MDL No. MFCD09954886
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₃Cl₂FN₂
  • Molecular Weight 217.03
  • Synonym(s) Quinazoline, 2,4-dichloro-8-fluoro-
  • SMILES Clc1nc(Cl)c2c(n1)c(F)ccc2

Description

2,4-Dichloro-8-fluoroquinazoline features a sterically constrained quinazoline core with strategically positioned halogens enabling direct functionalization in late-stage synthesis. The electron-deficient ring system facilitates nucleophilic substitution, while the fluorine atom enhances metabolic stability and modulates electronic properties for targeted bioactive molecule construction.

Application

2,4-Dichloro-8-fluoroquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinazoline-based scaffolds. Its ortho-chlorine and fluoro substituents facilitate selective nucleophilic substitution reactions, supporting the introduction of diverse amine and heterocyclic side chains under mild conditions. The compound exhibits excellent bench stability and ease of purification, making it well-suited for scalable synthesis and downstream derivatization in API development.

Synthesis

  • Route1
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    • In-stock
      2-Amino-3-fluorobenzenecarboxylic acid|CS-W002787
      825-22-9
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    • In-stock
      2,4-Dichloro-8-fluoroquinazoline|CS-W003702
      959237-64-0

    References

    • US2008/255156 A1, ; Page/Page column 10 ;
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 38, # 14 p. 2763 - 2773
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 38, # 14 p. 2763 - 2773

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   3.0757
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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