Lot numbers can be found on the outside label of a product:
2,4-dichloro-6-fluoroquinazoline
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CAS No. 134517-57-0
- Cat. No. CS-W001036
- Purity≥95%
- MDL No.MFCD09954884
*For research and further manufacturing use only, not for direct human use.
Structure of 134517-57-0
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General Information
- CAS No. 134517-57-0
- Cat. No. CS-W001036
- Purity ≥95%
- MDL No. MFCD09954884
- Storage -20°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₃Cl₂FN₂
- Molecular Weight 217.03
- Synonym(s) 4-dichloro-6-fluoroquinazoline
- SMILES Fc1ccc2nc(Cl)nc(Cl)c2c1
Description
2,4-Dichloro-6-fluoroquinazoline features a highly electron-deficient quinazoline core with orthogonal halogen substituents enabling selective cross-coupling. This bench-stable scaffold integrates readily into kinase inhibitor architectures and serves as a key building block for bioactive heterocycles in medicinal chemistry.
Application
2,4-Dichloro-6-fluoroquinazoline serves as a versatile building block in medicinal chemistry, enabling site-selective functionalization via cross-coupling and nucleophilic substitution. Its halogen pattern offers orthogonal reactivity for palladium-catalyzed coupling and amine displacement, facilitating rapid diversification of quinazoline scaffolds. Bench-stable and readily purified, it functions efficiently in the synthesis of kinase inhibitors and other bioactive heterocycles.
Synthesis
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Route1
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In-stock
88145-90-8 - ~72%
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In-stock
134517-57-0
References
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Smits, Rogier A.; De Esch, Iwan J. P.; Zuiderveld, Obbe P.; Broeker, Joachim; Sansuk, Kamonchanok; Guaita, Elena; Coruzzi, Gabriella; Adami, Maristella; Haaksma, Eric; Leurs, Rob Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 7855 - 7865
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Route2
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32315-10-9 -
In-stock
61272-77-3 - ~90%
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In-stock
134517-57-0
References
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Li, Zhenhua; Wu, Danli; Zhong, Weihui Heterocycles, 2012 , vol. 85, # 6 p. 1417 - 1426
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Route3
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In-stock
319-24-4 - ~%
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In-stock
134517-57-0
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 6 p. 1593 - 1597
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 25.78
- LogP 3.0757
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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