5-Fluoro-6-methoxypyridine-3-carboxylic acid

Name: 5-Fluoro-6-methoxypyridine-3-carboxylic acid
Brand: ChemScene
Availability: InStock
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CAS No. 953780-42-2
Cat. No. CS-0030501
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Fluoro-6-methoxypyridine-3-carboxylic acid|CS-0030501

Structure of 953780-42-2

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General Information

CAS No. 953780-42-2
Cat. No. CS-0030501
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆FNO₃
Molecular Weight 171.13
Synonym(s) 5-Fluoro-6-methoxynicotinic acid
SMILES O=C(C1=CC(F)=C(OC)N=C1)O

Description

5-Fluoro-6-methoxypyridine-3-carboxylic acid features a pyridine core functionalized with fluorine, methoxy, and carboxylic acid groups, enabling integration into diverse synthetic scaffolds. The electron-deficient aromatic ring pairs with the polar carboxylate for enhanced solubility and reactivity under standard conditions. This derivative serves as a key building block in medicinal chemistry and agrochemical synthesis.

Application

5-Fluoro-6-methoxypyridine-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its orthogonal reactivity profile—combining a carboxylic acid for amide/ester formation, a fluorine for nucleophilic substitution, and a methoxy group for selective derivatization—facilitates efficient scaffold diversification. Bench-stable and readily purified, it supports scalable synthesis workflows in API development.

Synthesis

Route1
- In-stock
  
  953780-40-0
- ~98%
- In-stock
  
  953780-42-2
References
- MERCK and CO., INC. Patent: WO2007/120729 A2, 2007 ; Location in patent: Page/Page column 57 ; WO 2007/120729 A2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 59.42
LogP 0.9275
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Fluoro-6-methoxypyridine-3-carboxylic acid

CAS No. 953780-42-2

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