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5-Fluoro-6-methoxy-3-pyridinecarboxaldehyde

  • CAS No. 884494-73-9

  • Cat. No. CS-0019349
  • Molecule weight155.13
  • Purity≥98%
  • MDL No.MFCD04112587

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-6-methoxy-3-pyridinecarboxaldehyde|CS-0019349

Structure of 884494-73-9

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General Information

  • CAS No. 884494-73-9
  • Cat. No. CS-0019349
  • Purity ≥98%
  • MDL No. MFCD04112587
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO₂
  • Molecular Weight 155.13
  • Synonym(s) 5-Fluoro-6-methoxynicotinaldehyde; 3-FLUORO-5-FORMYL-2-METHOXYPYRIDINE
  • SMILES O=CC1=CC(F)=C(OC)N=C1

Description

5-Fluoro-6-methoxy-3-pyridinecarboxaldehyde features a pyridine core functionalized with electron-withdrawing fluorine and methoxy groups, enhancing electrophilicity at the aldehyde site. This combination enables selective coupling in transition-metal-catalyzed reactions and facilitates incorporation into bioactive scaffolds requiring polar, electron-deficient heterocycles.

Application

5-Fluoro-6-methoxy-3-pyridinecarboxaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles via standard condensation and coupling reactions. Its ortho-fluoro and meta-methoxy substituents provide predictable electronic modulation and enhanced metabolic stability, while the aldehyde functionality facilitates efficient derivatization under mild conditions. The compound exhibits excellent bench stability and is compatible with common protecting group strategies, making it ideal for iterative synthesis workflows in API development.

Synthesis

  • Route1

    References

    • EP2022793 A1, ; Page/Page column 73 ; EP2022793 A1, ; Page/Page column 73 ; EP 2022793 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.0418
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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