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CS-W001157 4
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6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole-2-carbaldehyde

  • CAS No. 623564-38-5

  • Cat. No. CS-0000115
  • Purity≥97%
  • MDL No.MFCD11035720

*For research and further manufacturing use only, not for direct human use.

6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole-2-carbaldehyde|CS-0000115

Structure of 623564-38-5

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General Information

  • CAS No. 623564-38-5
  • Cat. No. CS-0000115
  • Purity ≥97%
  • MDL No. MFCD11035720
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O
  • Molecular Weight 136.15
  • Synonym(s) 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole-2-carboxaldehyde
  • SMILES O=CC1=CN2C(CCC2)=N1

Description

6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole-2-carbaldehyde features a fused heterocyclic core with a reactive aldehyde group at the 2-position. This electron-deficient scaffold integrates readily into synthetic sequences requiring site-specific functionalization. The compound exhibits bench-stable handling characteristics and serves as a key building block for bioactive molecule synthesis.

Application

6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole-2-carbaldehyde serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. The aldehyde functionality enables efficient coupling reactions, while the fused imidazole core provides structural rigidity and tunable electronic properties. Bench-stable and compatible with common protecting group strategies, it facilitates the construction of complex scaffolds via reductive amination, Ugi-type condensations, or transition-metal-catalyzed cross-couplings in standard synthetic workflows.

Synthesis

  • Route1
    • null|null
      19263-02-6
    • ~40%
    • In-stock
      6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole-2-carbaldehyde|CS-0000115
      623564-38-5

    References

    • WYETH Patent: WO2003/93279 A1, 2003 ; Location in patent: Page/Page column 62-63 ;
  • Route2
    • null|null
      623564-39-6
    • ~41%
    • In-stock
      6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole-2-carbaldehyde|CS-0000115
      623564-38-5

    References

    • WYETH Patent: WO2007/16134 A1, 2007 ; Location in patent: Page/Page column 35 ;
  • Route3
    • null|null
      623564-39-6
    • Pyrrolidin-2-imine (hydrochloride) Tipiracil  Impurity|CS-0229316
      7544-75-4
    • ~40%
    • In-stock
      6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole-2-carbaldehyde|CS-0000115
      623564-38-5

    References

    • WYETH Patent: WO2003/93277 A1, 2003 ; Location in patent: Page/Page column 80-81 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   34.89
  • LogP   0.6418
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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