1-(2-Methoxyethyl)-1H-pyrazol-4-amine

Name: 1-(2-Methoxyethyl)-1H-pyrazol-4-amine
Brand: ChemScene
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CAS No. 948570-74-9
Cat. No. CS-W005886
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-(2-Methoxyethyl)-1H-pyrazol-4-amine|CS-W005886

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General Information

CAS No. 948570-74-9
Cat. No. CS-W005886
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₁N₃O
Molecular Weight 141.17
Synonym(s) 4-Amino-1-(2-methoxyethyl)-1H-pyrazole
SMILES NC1=CN(CCOC)N=C1

Description

1-(2-Methoxyethyl)-1H-pyrazol-4-amine features a pyrazole core functionalized with an electron-donating amine at C4 and a polar methoxyethyl side chain, enhancing solubility and metabolic stability. This scaffold integrates readily into bioactive molecule design, offering favorable pharmacokinetic properties for medicinal chemistry applications.

Application

1-(2-Methoxyethyl)-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrazole-based scaffolds. Its amine functionality facilitates conjugation and derivatization, while the methoxyethyl side chain enhances solubility and modulates pharmacokinetic properties. The compound exhibits bench stability and compatibility with standard coupling reactions, making it well-suited for parallel synthesis and target-oriented library construction.

Synthesis

Route1
- In-stock
  
  948570-75-0
- ~%
- In-stock
  
  948570-74-9
References
- ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2007/99326 A1, 2007 ; Location in patent: Page/Page column 104 ; WO 2007/099326 A1
Route2
- In-stock
  
  2075-46-9
- 6482-24-2
- ~%
- In-stock
  
  948570-74-9
References
- INCYTE CORPORATION; WU, Liangxing; ZHANG, Colin; HE, Chunhong; SUN, Yaping; LU, Liang; QIAN, Ding-Quan; XU, Meizhong; ZHUO, Jincong; YAO, Wenqing Patent: WO2014/7951 A2, 2014 ; Location in patent: Page/Page column 241 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 53.07
LogP 0.1117
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Ether

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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1-(2-Methoxyethyl)-1H-pyrazol-4-amine

CAS No. 948570-74-9

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