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CS-W001157 4
Total: USD 88.00

1-Ethyl-1H-pyrazol-4-amine

  • CAS No. 876343-24-7

  • Cat. No. CS-0052571
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Ethyl-1H-pyrazol-4-amine|CS-0052571

Structure of 876343-24-7

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General Information

  • CAS No. 876343-24-7
  • Cat. No. CS-0052571
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉N₃
  • Molecular Weight 111.15
  • Synonym(s) 4-Amino-1-ethylpyrazole
  • SMILES CCN1C=C(N)C=N1

Description

1-Ethyl-1H-pyrazol-4-amine features a pyrazole core with an ethyl group at N1 and a primary amine at C4, enabling versatile coupling reactions. This bench-stable, moisture-tolerant scaffold integrates readily into bioactive molecules, offering enhanced solubility and metabolic stability in pharmaceutical development workflows.

Application

1-Ethyl-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrazole-based heterocycles through standard coupling and functionalization reactions. Its ethyl substituent enhances solubility and metabolic stability, while the primary amine facilitates facile derivatization. The compound exhibits good bench stability and compatibility with common protecting group strategies, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • 1-Ethyl-4-nitro-1h-pyrazole|CS-0124121
      58793-45-6
    • ~99%
    • In-stock
      1-Ethyl-1H-pyrazol-4-amine|CS-0052571
      876343-24-7

    References

    • GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy B. Patent: WO2012/31004 A1, 2012 ; Location in patent: Page/Page column 84-85 ; WO 2012/031004 A1
  • Route2
    • In-stock
      4-Nitropyrazole|CS-W002458
      2075-46-9
    • null|null
      75-03-6
    • ~%
    • In-stock
      1-Ethyl-1H-pyrazol-4-amine|CS-0052571
      876343-24-7

    References

    • WO2011/48082 A1, ; Page/Page column 63; 64; 69; 70 ; WO 2011/048082 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   0.4852
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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