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CS-W001157 4
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1-Hydroxy-6-oxo-1,6-dihydropyridine-2-carboxylic acid

  • CAS No. 94781-89-2

  • Cat. No. CS-W019344
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Hydroxy-6-oxo-1,6-dihydropyridine-2-carboxylic acid|CS-W019344

Structure of 94781-89-2

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General Information

  • CAS No. 94781-89-2
  • Cat. No. CS-W019344
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅NO₄
  • Molecular Weight 155.11
  • Synonym(s) 1-Hydroxy-6-oxo-1,6-dihydro-pyridine-2-carboxylic acid
  • SMILES O=C(C1=CC=CC(N1O)=O)O

Description

1-Hydroxy-6-oxo-1,6-dihydropyridine-2-carboxylic acid features a reactive pyridine core with orthogonal functional groups enabling direct integration into heterocyclic synthesis. The hydroxyl and carboxylic acid moieties facilitate coupling reactions, while the enone system supports conjugate addition pathways under mild conditions. This scaffold offers enhanced solubility and stability in aqueous and polar organic media.

Application

1-Hydroxy-6-oxo-1,6-dihydropyridine-2-carboxylic acid serves as a versatile scaffold for heterocyclic synthesis, enabling efficient access to pyridine-based building blocks. Its conjugated enone–carboxylic acid motif supports diverse functionalization via nucleophilic addition, condensation, and cyclization reactions. The compound exhibits bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   79.53
  • LogP   -0.2162
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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