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CS-W001157 4
Total: USD 88.00

N3-PEG4-C2-NHS ester

  • CAS No. 944251-24-5

  • Cat. No. CS-0105092
  • Purity≥95%
  • MDL No.MFCD13184948

*For research and further manufacturing use only, not for direct human use.

N3-PEG4-C2-NHS ester|CS-0105092

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General Information

  • CAS No. 944251-24-5
  • Cat. No. CS-0105092
  • Purity ≥95%
  • MDL No. MFCD13184948
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₄N₄O₈
  • Molecular Weight 388.37
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCN=[N+]=[N-]

Description

N3-PEG4-C2-NHS ester is a bifunctional crosslinker featuring a reactive NHS ester and a terminal azide group. This reagent enables efficient conjugation via click chemistry, combining the stability of PEGylation with selective bioorthogonal ligation. Ideal for labeling biomolecules under physiological conditions.

Application

N3-PEG4-C2-NHS ester serves as a versatile, bifunctional linker for site-specific conjugation in bioconjugate chemistry. The NHS ester group readily reacts with primary amines under physiological conditions, while the terminal azide enables efficient copper-catalyzed or strain-promoted cycloaddition. Its PEG4 spacer provides enhanced solubility and reduced non-specific binding, making it ideal for labeling biomolecules, constructing protein-drug conjugates, or functionalizing surfaces with controlled spacing and stability.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS02
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H228-H315-H319
Precautionary Statements : P210-P240-P241-P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-P370+P378

Quality Control

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Computational Chemistry Data

  • TPSA   149.36
  • LogP   0.3604
  • H_Acceptors   9
  • H_Donors   0
  • Rotatable_Bonds   16

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