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(3S)-1-[(1,1-Dimethylethoxy)carbonyl]-3-piperidineacetic acid

  • CAS No. 941289-27-6

  • Cat. No. CS-0028290
  • Purity≥97%
  • MDL No.MFCD03094722

*For research and further manufacturing use only, not for direct human use.

(3S)-1-[(1,1-Dimethylethoxy)carbonyl]-3-piperidineacetic acid|CS-0028290

Structure of 941289-27-6

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General Information

  • CAS No. 941289-27-6
  • Cat. No. CS-0028290
  • Purity ≥97%
  • MDL No. MFCD03094722
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₄
  • Molecular Weight 243.30
  • Synonym(s) (S)-2-(1-(tert-butoxycarbonyl)piperidin-3-yl)acetic acid
  • SMILES CC(C)(C)OC(N1C[C@@H](CCC1)CC(O)=O)=O

Description

This chiral piperidine derivative features a carbamate-protected amine and a sterically hindered tert-butyl group, enabling stable incorporation into peptide synthesis workflows. The (3S) stereochemistry ensures high diastereoselectivity in coupling reactions, while the pendant carboxylic acid facilitates efficient conjugation.

Application

(3S)-1-[(1,1-Dimethylethoxy)carbonyl]-3-piperidineacetic acid serves as a stereochemically defined building block for the synthesis of bioactive piperidine derivatives. Its Cbz-protected amine and carboxylic acid functionality enable efficient coupling reactions and orthogonal functional group manipulation. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative medicinal chemistry campaigns and API intermediate development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.1082
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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