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(2-fluoro-4-methoxyphenyl)hydrazine;hydrochloride

  • CAS No. 940298-93-1

  • Cat. No. CS-0038900
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2-fluoro-4-methoxyphenyl)hydrazine;hydrochloride|CS-0038900

Structure of 940298-93-1

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General Information

  • CAS No. 940298-93-1
  • Cat. No. CS-0038900
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀ClFN₂O
  • Molecular Weight 192.62
  • Synonym(s) (2-fluoro-4-methoxyphenyl)hydrazine,hydrochloride
  • SMILES COC1=CC(=C(C=C1)NN)F.Cl

Description

(2-Fluoro-4-methoxyphenyl)hydrazine hydrochloride serves as a reactive hydrazine derivative for constructing heterocyclic scaffolds in medicinal chemistry. The electron-rich aromatic core, enhanced by the methoxy group, facilitates efficient coupling reactions. This bench-stable salt enables straightforward incorporation into diverse synthetic pathways under standard conditions.

Application

(2-Fluoro-4-methoxyphenyl)hydrazine hydrochloride serves as a reliable building block for the synthesis of fluorinated heterocycles and azo dyes. Its hydrazine functionality enables straightforward cyclization with carbonyl compounds or electrophilic precursors, facilitating access to bioactive scaffolds. The compound exhibits good bench stability and ease of handling, with the methoxy and fluoro substituents offering predictable electronic modulation and enhanced metabolic stability in downstream applications.

Synthesis

  • Route1

    References

    • Heredia-Moya, Jorge; Hayakawa, Yoshio; Kirk, Kenneth L. Journal of Fluorine Chemistry, 2006 , vol. 127, # 9 p. 1256 - 1260

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   47.28
  • LogP   1.5417
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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