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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-methoxyaniline

  • CAS No. 458-52-6

  • Cat. No. CS-W007366
  • Purity≥96%
  • MDL No.MFCD00047827

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-methoxyaniline|CS-W007366

Structure of 458-52-6

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General Information

  • CAS No. 458-52-6
  • Cat. No. CS-W007366
  • Purity ≥96%
  • MDL No. MFCD00047827
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FNO
  • Molecular Weight 141.14
  • Synonym(s) 4-Methoxy-2-fluoroaniline
  • SMILES C1=C(C(=CC=C1OC)N)F

Description

2-Fluoro-4-methoxyaniline features a fluorine atom at the ortho position and a methoxy group at the para position relative to the amino functionality, delivering enhanced electron-donating character and improved metabolic stability. This substitution pattern enables efficient incorporation into pharmaceutical intermediates and advanced organic materials.

Application

2-Fluoro-4-methoxyaniline serves as a valuable building block in medicinal chemistry, enabling the construction of fluorinated aromatic scaffolds. Its ortho-fluoro and para-methoxy substituents offer enhanced metabolic stability and modulated electronic properties. The amine group facilitates direct coupling reactions, while the molecule exhibits good bench stability and compatibility with standard purification methods.

Synthesis

  • Route1

    References

    • GLAXO GROUP LIMITED Patent: WO2006/2047 A2, 2006 ; Location in patent: Page/Page column 69-70 ;
  • Route2
    • null|null
      217314-31-3
    • ~69%
    • In-stock
      2-Fluoro-4-methoxyaniline|CS-W007366
      458-52-6

    References

    • Ragan, John A.; Makowski, Teresa W.; Castaldi, Michael J.; Hill, Paul D. Synthesis, 1998 , # 11 p. 1599 - 1603
  • Route3
    • null|null
      209353-23-1
    • ~82%
    • In-stock
      2-Fluoro-4-methoxyaniline|CS-W007366
      458-52-6

    References

    • Stadlwieser, Josef; Barbier, Pierre; Taylor, Sven Helvetica Chimica Acta, 1998 , vol. 81, # 6 p. 1088 - 1094

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.4165
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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