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CS-W001157 4
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tert-Butyl 2-(aminomethyl)azetidine-1-carboxylate

  • CAS No. 939760-37-9

  • Cat. No. CS-W018739
  • Purity≥96%
  • MDL No.MFCD08544502

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2-(aminomethyl)azetidine-1-carboxylate|CS-W018739

Structure of 939760-37-9

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General Information

  • CAS No. 939760-37-9
  • Cat. No. CS-W018739
  • Purity ≥96%
  • MDL No. MFCD08544502
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₈N₂O₂
  • Molecular Weight 186.25
  • Synonym(s) 2-Aminomethyl-azetidine-1-carboxylic acid tert-butyl ester
  • SMILES O=C(N1C(CN)CC1)OC(C)(C)C

Description

tert-Butyl 2-(aminomethyl)azetidine-1-carboxylate is a bench-stable, moisture-tolerant azetidine derivative featuring a protected primary amine and a strained four-membered ring. This scaffold integrates readily into peptide-based drug candidates, offering enhanced metabolic stability and conformational rigidity. The tert-butyl carbamate group enables straightforward deprotection under mild acidic conditions, facilitating downstream functionalization in synthetic medicinal chemistry workflows.

Application

tert-Butyl 2-(aminomethyl)azetidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling the construction of azetidine-containing scaffolds via standard amine functionalization. The protected amine and carboxylate groups offer orthogonal reactivity, facilitating selective transformations in multi-step syntheses. Its bench-stable nature and ease of purification support scalable applications in API development and target-oriented synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   0.9545
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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