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tert-Butyl N-[(2R)-azetidin-2-ylmethyl]carbamate hydrochloride

  • CAS No. 1818843-14-9

  • Cat. No. CS-0048024
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl N-[(2R)-azetidin-2-ylmethyl]carbamate hydrochloride|CS-0048024

Structure of 1818843-14-9

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General Information

  • CAS No. 1818843-14-9
  • Cat. No. CS-0048024
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₉ClN₂O₂
  • Molecular Weight 222.71
  • Synonym(s) TERT-BUTYL N-[(2R)-AZETIDIN-2-YLMETHYL]CARBAMATE HCL
  • SMILES Cl.CC(C)(C)OC(=O)NC[C@H]1CCN1

Description

tert-Butyl N-[(2R)-azetidin-2-ylmethyl]carbamate hydrochloride offers a stable, moisture-tolerant platform for introducing chiral azetidine units in synthetic sequences. The (2R)-configured azetidinylmethyl moiety integrates readily into bioactive scaffolds, while the tert-butyl carbamate group enables selective protection and orthogonal deprotection under mild conditions. This hydrochloride salt enhances solubility and handling in aqueous or polar organic media, streamlining downstream processing in medicinal chemistry workflows.

Application

tert-Butyl N-[(2R)-azetidin-2-ylmethyl]carbamate hydrochloride serves as a stable, bench-ready building block for the synthesis of bioactive azetidine-containing scaffolds. The protected amine enables orthogonal functionalization in late-stage diversification, while the chiral (2R)-azetidin-2-ylmethyl moiety provides a well-defined stereochemical handle for medicinal chemistry campaigns. Its compatibility with standard coupling and reduction protocols facilitates efficient access to complex heterocyclic architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.36
  • LogP   1.2948
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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