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CS-W001157 4
Total: USD 88.00

6-(Trifluoromethyl)pyridazin-3-amine

  • CAS No. 935777-24-5

  • Cat. No. CS-W018477
  • Purity≥97%
  • MDL No.MFCD13189559

*For research and further manufacturing use only, not for direct human use.

6-(Trifluoromethyl)pyridazin-3-amine|CS-W018477

Structure of 935777-24-5

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General Information

  • CAS No. 935777-24-5
  • Cat. No. CS-W018477
  • Purity ≥97%
  • MDL No. MFCD13189559
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄F₃N₃
  • Molecular Weight 163.10
  • Synonym(s) 6-trifluoromethyl-3-pyridazinamine
  • SMILES NC1=NN=C(C(F)(F)F)C=C1

Description

6-(Trifluoromethyl)pyridazin-3-amine features a trifluoromethyl group that imparts strong electron-withdrawing character and enhanced metabolic stability. This nitrogen-rich heterocycle integrates readily into medicinal chemistry scaffolds, offering improved solubility and binding affinity in target-directed drug discovery programs.

Application

6-(Trifluoromethyl)pyridazin-3-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its trifluoromethyl group enhances metabolic stability and modulates lipophilicity, while the pyridazinamine core offers reliable reactivity in amide bond formation, Suzuki-Miyaura coupling, and electrophilic functionalization. Bench-stable and readily purified, it functions as a key intermediate in the synthesis of kinase inhibitors and other pharmaceutical scaffolds.

Synthesis

  • Route1

    References

    • JANSSEN PHARMACEUTICA N.V. Patent: WO2007/48779 A1, 2007 ; Location in patent: Page/Page column 16 ; WO 2007/048779 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.0776
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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