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CS-W001157 4
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6-(Difluoromethyl)pyridazin-3-amine

  • CAS No. 1706450-11-4

  • Cat. No. CS-0129095
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-(Difluoromethyl)pyridazin-3-amine|CS-0129095

Structure of 1706450-11-4

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General Information

  • CAS No. 1706450-11-4
  • Cat. No. CS-0129095
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅F₂N₃
  • Molecular Weight 145.11
  • Synonym(s) None
  • SMILES NC1=NN=C(C(F)F)C=C1

Description

6-(Difluoromethyl)pyridazin-3-amine features a difluoromethyl group appended to a pyridazin-3-amine scaffold, delivering enhanced metabolic stability and favorable lipophilicity. This electron-deficient heterocycle integrates readily into medicinal chemistry programs targeting kinase inhibitors and CNS-penetrant therapeutics. The fluorinated side chain improves membrane permeability while maintaining solubility under standard conditions.

Application

6-(Difluoromethyl)pyridazin-3-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. The difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties, while the pyridazinamine core supports diverse transformations including Suzuki-Miyaura coupling, amide formation, and electrophilic substitution. Its bench-stable nature and compatibility with common protecting groups facilitate efficient synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.9964
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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