1-Bromo-5-fluoro-4-nitro-2-(trifluoromethyl)benzene

Name: 1-Bromo-5-fluoro-4-nitro-2-(trifluoromethyl)benzene
Brand: ChemScene
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CAS No. 932374-77-1
Cat. No. CS-0636896
Purity≥97%
MDL No.None

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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1-Bromo-5-fluoro-4-nitro-2-(trifluoromethyl)benzene|CS-0636896

Structure of 932374-77-1

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General Information

CAS No. 932374-77-1
Cat. No. CS-0636896
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₂BrF₄NO₂
Molecular Weight 287.99
Synonym(s) None
SMILES FC(C1=CC([N+]([O-])=O)=C(F)C=C1Br)(F)F

Description

1-Bromo-5-fluoro-4-nitro-2-(trifluoromethyl)benzene features a highly electron-deficient aromatic core stabilized by strong inductive effects from the trifluoromethyl and nitro groups. This configuration enables efficient palladium-catalyzed cross-coupling reactions under mild conditions, with the bromo group serving as a reliable handle for C–C bond formation. The molecule exhibits excellent bench stability and compatibility with diverse reaction environments.

Application

1-Bromo-5-fluoro-4-nitro-2-(trifluoromethyl)benzene serves as a versatile building block for constructing complex fluorinated aromatic scaffolds. Its orthogonal reactivity enables palladium-catalyzed cross-coupling, nucleophilic substitution, and sequential functionalization. The trifluoromethyl and nitro groups enhance metabolic stability and modulate electronic properties, while the bromo and fluoro substituents provide distinct sites for further derivatization. Bench-stable and compatible with standard purification protocols, it facilitates efficient synthesis of advanced intermediates for pharmaceutical and agrochemical applications.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 43.14
LogP 3.5152
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-Bromo-5-fluoro-4-nitro-2-(trifluoromethyl)benzene

CAS No. 932374-77-1

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