Methyl 1-oxoisoindoline-5-carboxylate

Name: Methyl 1-oxoisoindoline-5-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 926307-72-4
Cat. No. CS-0112751
Purity≥98%
MDL No.MFCD13177815

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Methyl 1-oxoisoindoline-5-carboxylate|CS-0112751

Structure of 926307-72-4

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 926307-72-4
Cat. No. CS-0112751
Purity ≥98%
MDL No. MFCD13177815
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₉NO₃
Molecular Weight 191.18
Synonym(s) Methyl 1-oxo-2,3-dihydro-1H-isoindole-5-carboxylate
SMILES O=C(C1=CC2=C(C(NC2)=O)C=C1)OC

Description

Methyl 1-oxoisoindoline-5-carboxylate is a bench-stable, moisture-tolerant heterocyclic ester featuring a fused tricyclic core with a strategically positioned carbonyl and ester group. This scaffold integrates readily into synthetic sequences for pharmaceutical intermediates, enabling efficient access to bioactive isoindoline derivatives through functional group manipulation.

Application

Methyl 1-oxoisoindoline-5-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to isoindoline-based scaffolds prevalent in bioactive molecules. Its electrophilic carbonyl at the 1-position and ester functionality facilitate diverse transformations, including reductive amination, nucleophilic substitution, and transition-metal-catalyzed coupling reactions. The compound exhibits good bench stability and ease of purification, making it well-suited for iterative synthesis workflows in API development.

Synthesis

Route1
- 67-56-1
- In-stock
  
  552330-86-6
- 201230-82-2
- ~%
- In-stock
  
  926307-72-4
References
- AMGEN INC.; BISWAS, Kaustav; BROWN, James; CHEN, Jian, J.; GORE, Vijay, Keshav; HARRIED, Scott; HORNE, Daniel, B.; KALLER, Matthew, R.; LIU, Qingyian; MA, Vu, Van; MONENSCHEIN, Holger; NGUYEN, Thomas, T.; YUAN, Chester, Chenguang; ZHONG, Wenge; ST. JEAN, David, J., Jr. Patent: WO2012/177893 A2, 2012 ; Location in patent: Page/Page column 198 ; WO 2012/177893 A2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 55.4
LogP 0.7166
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Key Words

Methyl 1-oxoisoindoline-5-carboxylate sigmaMethyl 1-oxoisoindoline-5-carboxylate manufacturerMethyl 1-oxoisoindoline-5-carboxylate priceMethyl 1-oxoisoindoline-5-carboxylate structureMethyl 1-oxoisoindoline-5-carboxylate SDSbuy Methyl 1-oxoisoindoline-5-carboxylateMethyl 1-oxoisoindoline-5-carboxylate supplierMethyl 1-oxoisoindoline-5-carboxylate usesMethyl 1-oxoisoindoline-5-carboxylate molecular weightprice of Methyl 1-oxoisoindoline-5-carboxylateMethyl 1-oxoisoindoline-5-carboxylate chemical name formula of Methyl 1-oxoisoindoline-5-carboxylate

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Methyl 1-oxoisoindoline-5-carboxylate

CAS No. 926307-72-4

Recommended Products