Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

3-Bromo-2-methoxyaniline

  • CAS No. 116557-46-1

  • Cat. No. CS-W006132
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-methoxyaniline|CS-W006132

Structure of 116557-46-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 116557-46-1
  • Cat. No. CS-W006132
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BrNO
  • Molecular Weight 202.05
  • Synonym(s) 3-Bromo-o-anisidine
  • SMILES NC1=CC=CC(Br)=C1OC

Description

3-Bromo-2-methoxyaniline features a bromine substituent at the meta position relative to the amino group and a methoxy group ortho to the amine. This electron-rich aromatic scaffold enables direct coupling in cross-coupling reactions and serves as a key intermediate in the synthesis of functionalized pharmaceuticals and agrochemicals.

Application

3-Bromo-2-methoxyaniline serves as a versatile building block in medicinal chemistry, enabling direct incorporation into heterocyclic scaffolds via electrophilic substitution or cross-coupling reactions. The ortho-methoxy group enhances solubility and modulates reactivity, while the bromine facilitates palladium-catalyzed couplings. Bench-stable and readily purified, it functions effectively in standard synthetic workflows for API development and target-oriented synthesis.

Synthesis

  • Route1

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2008/120003 A1, 2008 ; Location in patent: Page/Page column 49-50 ; WO 2008/120003 A1
  • Route2
    • In-stock
      2-Bromo-6-nitrophenol|CS-W021626
      13073-25-1
    • null|null
      74-88-4
    • ~99%
    • In-stock
      3-Bromo-2-methoxyaniline|CS-W006132
      116557-46-1

    References

    • BRISTOL-MYERS SQUIBB COMPANY; L'HEUREUX, Alexandre; HIEBERT, Sheldon; HU, Carol; LAM, Patrick Y.S.; LLOYD, John; PI, Zulan; QIAO, Jennifer X.; THIBEAULT, Carl; TORA, George O.; YANG, Wu; WANG, Yufeng; WANG, Tammy C.; BOWSHER, Michael S.; RUEL, Rejean Patent: WO2014/22343 A1, 2014 ; Location in patent: Paragraph 00162 ;
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 56, p. 1787,1790

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.0399
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 3-Bromo-2-methoxyaniline sigma3-Bromo-2-methoxyaniline manufacturer3-Bromo-2-methoxyaniline price3-Bromo-2-methoxyaniline structure3-Bromo-2-methoxyaniline SDSbuy 3-Bromo-2-methoxyaniline3-Bromo-2-methoxyaniline supplier3-Bromo-2-methoxyaniline uses3-Bromo-2-methoxyaniline molecular weightprice of 3-Bromo-2-methoxyaniline3-Bromo-2-methoxyaniline chemical name formula of 3-Bromo-2-methoxyaniline
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label