Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

5-Bromo-2-methoxyaniline

  • CAS No. 6358-77-6

  • Cat. No. CS-W007885
  • Purity≥98%
  • MDL No.MFCD04037882

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-methoxyaniline|CS-W007885

Structure of 6358-77-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 6358-77-6
  • Cat. No. CS-W007885
  • Purity ≥98%
  • MDL No. MFCD04037882
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BrNO
  • Molecular Weight 202.05
  • Synonym(s) benzenamine,5-bromo-2-methoxy-
  • SMILES NC1=CC(Br)=CC=C1OC

Description

5-Bromo-2-methoxyaniline features a bromine substituent at the 5-position and a methoxy group at the 2-position, conferring enhanced electron density and improved solubility in polar organic solvents. This aniline derivative serves as a key intermediate in the synthesis of pharmaceuticals and functional dyes, offering high reactivity in coupling reactions under standard conditions.

Application

5-Bromo-2-methoxyaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted heterocycles via Pd-catalyzed cross-coupling reactions. The bromo group facilitates reliable Suzuki, Stille, or Negishi coupling, while the methoxy functionality offers moderate electron donation and orthogonal reactivity. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for iterative synthetic campaigns requiring functional group tolerance and predictable regiochemistry.

Synthesis

  • Route1

    References

    • BRISTOL-MYERS SQUIBB COMPANY; L'HEUREUX, Alexandre; HIEBERT, Sheldon; HU, Carol; LAM, Patrick Y.S.; LLOYD, John; PI, Zulan; QIAO, Jennifer X.; THIBEAULT, Carl; TORA, George O.; YANG, Wu; WANG, Yufeng; WANG, Tammy C.; BOWSHER, Michael S.; RUEL, Rejean Patent: WO2014/22343 A1, 2014 ; Location in patent: Paragraph 00169 ;
  • Route2
    • In-stock
      4-Bromo-2-nitroanisole|CS-W009144
      33696-00-3
    • null|null
      7439-89-6
    • ~%
    • In-stock
      5-Bromo-2-methoxyaniline|CS-W007885
      6358-77-6

    References

    • US2003/187001 A1, ; US 20030187001 A1
  • Route3
    • 4,5-Dibromo-2-methoxyaniline|CS-1716822
      367521-06-0
    • ~80%
    • In-stock
      5-Bromo-2-methoxyaniline|CS-W007885
      6358-77-6

    References

    • Choi; Chi Journal of the American Chemical Society, 2001 , vol. 123, # 37 p. 9202 - 9203

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317-H401
Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P363-P391-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.0399
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 5-Bromo-2-methoxyaniline sigma5-Bromo-2-methoxyaniline manufacturer5-Bromo-2-methoxyaniline price5-Bromo-2-methoxyaniline structure5-Bromo-2-methoxyaniline SDSbuy 5-Bromo-2-methoxyaniline5-Bromo-2-methoxyaniline supplier5-Bromo-2-methoxyaniline uses5-Bromo-2-methoxyaniline molecular weightprice of 5-Bromo-2-methoxyaniline5-Bromo-2-methoxyaniline chemical name formula of 5-Bromo-2-methoxyaniline
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label