Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4,6-Dichloronicotinic acid

  • CAS No. 73027-79-9

  • Cat. No. CS-W002553
  • Purity≥97%
  • MDL No.MFCD00234146

*For research and further manufacturing use only, not for direct human use.

4,6-Dichloronicotinic acid|CS-W002553

Structure of 73027-79-9

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 73027-79-9
  • Cat. No. CS-W002553
  • Purity ≥97%
  • MDL No. MFCD00234146
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃Cl₂NO₂
  • Molecular Weight 192.00
  • Synonym(s) None
  • SMILES O=C(O)C1=CN=C(Cl)C=C1Cl

Description

4,6-Dichloronicotinic acid features a pyridine ring bearing two chlorine substituents at the 4- and 6-positions, delivering enhanced electron-withdrawing character. This configuration supports efficient coupling reactions and facilitates incorporation into bioactive scaffolds requiring halogenated heterocyclic motifs. The compound exhibits bench-stable handling and compatibility with standard synthetic protocols.

Application

4,6-Dichloronicotinic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to functionalized heterocycles via standard coupling reactions. Its ortho-dichloro substitution pattern facilitates directed metalation and palladium-catalyzed cross-coupling, while the carboxylic acid group supports direct derivatization or salt formation for improved solubility and purification. The compound exhibits excellent bench stability and compatibility with diverse reaction conditions, making it a reliable scaffold for API development and process optimization.

Synthesis

  • Route1

    References

    • Platts, Michelle Y.; Barber, Christopher G.; Chiva, Jean-Yves; Eastwood, Rachel L.; Fenwick, David R.; Paradowski, Kerry A.; Blakemore, David C. Tetrahedron Letters, 2011 , vol. 52, # 4 p. 512 - 514
  • Route2

    References

    • Fucini, Raymond V.; Hanan, Emily J.; Romanowski, Michael J.; Elling, Robert A.; Lew, Willard; Barr, Kenneth J.; Zhu, Jiang; Yoburn, Joshua C.; Liu, Yang; Fahr, Bruce T.; Fan, Junfa; Lu, Yafan; Pham, Phuongly; Choong, Ingrid C.; VanderPorten, Erica C.; Bui, Minna; Purkey, Hans E.; Evanchik, Marc J.; Yang, Wenjin Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5648 - 5652
  • Route3
    • null|null
      124-38-9
    • In-stock
      2,4-Dichloro-5-iodopyridine|CS-W021506
      343781-49-7
    • ~80%
    • In-stock
      4,6-Dichloronicotinic acid|CS-W002553
      73027-79-9

    References

    • Marzi, Elena; Bigi, Anna; Schlosser, Manfred European Journal of Organic Chemistry, 2001 , # 7 p. 1371 - 1376

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.0866
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 4,6-Dichloronicotinic acid sigma4,6-Dichloronicotinic acid manufacturer4,6-Dichloronicotinic acid price4,6-Dichloronicotinic acid structure4,6-Dichloronicotinic acid SDSbuy 4,6-Dichloronicotinic acid4,6-Dichloronicotinic acid supplier4,6-Dichloronicotinic acid uses4,6-Dichloronicotinic acid molecular weightprice of 4,6-Dichloronicotinic acid4,6-Dichloronicotinic acid chemical name formula of 4,6-Dichloronicotinic acid
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label