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CS-W001157 4
Total: USD 88.00

3-Iodo-1-methyl-1H-pyrazole

  • CAS No. 92525-10-5

  • Cat. No. CS-W000413
  • Purity≥97%
  • MDL No.MFCD08435890
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Iodo-1-methyl-1H-pyrazole|CS-W000413

Structure of 92525-10-5

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Description

3-Iodo-1-methyl-1H-pyrazole is a bench-stable, electron-deficient heterocycle featuring a reactive iodine substituent at the 3-position. This functional group enables efficient coupling in cross-coupling reactions, particularly in palladium-catalyzed transformations. The methyl group at the 1-position enhances solubility and modulates electronic properties, making this compound valuable for constructing complex nitrogen-containing scaffolds in medicinal chemistry and materials science.

Application

3-Iodo-1-methyl-1H-pyrazole serves as a versatile building block in medicinal chemistry and cross-coupling synthesis. The iodine substituent enables reliable Suzuki, Stille, and Negishi coupling reactions, facilitating the construction of biaryl and heteroaryl scaffolds. Its methyl group enhances stability and solubility, while the pyrazole core provides a rigid, polar scaffold compatible with diverse functional groups. This compound offers excellent bench stability, ease of handling, and straightforward purification—ideal for modular drug discovery and API intermediate development.

General Information

  • CAS No. 92525-10-5
  • Cat. No. CS-W000413
  • Purity ≥97%
  • MDL No. MFCD08435890
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅IN₂
  • Molecular Weight 208.00
  • Synonym(s) 3-Iodo-1-methylpyrazole
  • SMILES CN1C=CC(I)=N1

Computational Chemistry Data

  • TPSA   17.82
  • LogP   1.0247
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group :
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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