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CS-W001157 4
Total: USD 88.00

5-Iodo-1-methyl-1H-pyrazole

  • CAS No. 34091-51-5

  • Cat. No. CS-D0852
  • Purity≥96%
  • MDL No.MFCD11109327
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Iodo-1-methyl-1H-pyrazole|CS-D0852

Structure of 34091-51-5

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Description

5-Iodo-1-methyl-1H-pyrazole is a bench-stable heterocyclic reagent featuring a iodinated pyrazole core with a methyl group at the 1-position. This configuration enables direct coupling in transition-metal-catalyzed transformations, particularly Suzuki-Miyaura and Sonogashira reactions. The electron-deficient nature of the ring enhances reactivity in cross-coupling protocols. Its moisture-tolerant handling simplifies integration into synthetic workflows.

Application

5-Iodo-1-methyl-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura and Sonogashira transformations. The iodide functionality provides high reactivity under standard conditions, while the 1-methylpyrazole core offers excellent bench stability and compatibility with diverse functional groups. This compound facilitates efficient access to substituted pyrazole scaffolds prevalent in bioactive molecules and drug discovery programs.

General Information

  • CAS No. 34091-51-5
  • Cat. No. CS-D0852
  • Purity ≥96%
  • MDL No. MFCD11109327
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅IN₂
  • Molecular Weight 208.00
  • Synonym(s) 1-Methyl-5-iodopyrazole
  • SMILES CN1N=CC=C1I

Computational Chemistry Data

  • TPSA   17.82
  • LogP   1.0247
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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