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tert-Butyl 2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate

  • CAS No. 924869-27-2

  • Cat. No. CS-0100007
  • Purity≥97%
  • MDL No.MFCD08689720

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate|CS-0100007

Structure of 924869-27-2

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General Information

  • CAS No. 924869-27-2
  • Cat. No. CS-0100007
  • Purity ≥97%
  • MDL No. MFCD08689720
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₇N₃O₂
  • Molecular Weight 223.27
  • Synonym(s) tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate
  • SMILES O=C(N1CCC2=NNC=C2C1)OC(C)(C)C

Description

tert-Butyl 2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate is a bench-stable heterocyclic building block featuring a protected pyrazolopyridine core. This electron-rich scaffold integrates readily into medicinal chemistry campaigns, enabling efficient access to bioactive analogs through straightforward deprotection and functionalization.

Application

tert-Butyl 2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate serves as a versatile heterocyclic building block for medicinal chemistry and synthetic organic applications. The pyrazolopyridine core provides a rigid, electron-rich scaffold with defined regiochemistry, enabling selective functionalization at the C5 position. The tert-butyl ester group offers excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. This compound functions effectively in Suzuki-Miyaura, Buchwald-Hartwig, and reductive amination reactions, supporting diverse downstream derivatization in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P405-P501

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Computational Chemistry Data

  • TPSA   58.22
  • LogP   1.7029
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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