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CS-W001157 4
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Methyl 1-aminocyclobutanecarboxylate hydrochloride

  • CAS No. 92398-47-5

  • Cat. No. CS-W005628
  • Purity≥97%
  • MDL No.MFCD04115288

*For research and further manufacturing use only, not for direct human use.

Methyl 1-aminocyclobutanecarboxylate hydrochloride|CS-W005628

Structure of 92398-47-5

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General Information

  • CAS No. 92398-47-5
  • Cat. No. CS-W005628
  • Purity ≥97%
  • MDL No. MFCD04115288
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClNO₂
  • Molecular Weight 165.62
  • Synonym(s) 1-Amino-1-cyclobutanecarboxylic acid methylester hydrochloride
  • SMILES COC(C1(N)CCC1)=O.Cl

Description

Methyl 1-aminocyclobutanecarboxylate hydrochloride offers a rigid, conformationally constrained cyclobutane scaffold with a protonated amine and ester functionality. This bench-stable salt facilitates direct incorporation into peptide-like sequences or synthetic intermediates requiring a sterically defined, electron-rich nitrogen center.

Application

Methyl 1-aminocyclobutanecarboxylate hydrochloride serves as a versatile building block for cyclobutane-containing pharmaceutical intermediates. The protected amine and ester functionalities enable sequential transformations, including coupling reactions and selective deprotection. Its bench-stable nature and compatibility with standard synthetic protocols facilitate efficient access to bioactive scaffolds in medicinal chemistry.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      1-Aminocyclobutanecarboxylic acid|CS-D0209
      22264-50-2
    • ~85%
    • In-stock
      Methyl 1-aminocyclobutanecarboxylate hydrochloride|CS-W005628
      92398-47-5

    References

    • Journal of the American Chemical Society, , vol. 119, # 49 p. 11807 - 11816
  • Route2

    References

    • US2004/48802 A1, ; US 20040048802 A1
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 119, # 49 p. 11807 - 11816

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   0.4626
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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