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CS-W001157 4
Total: USD 88.00

5-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride

  • CAS No. 923591-51-9

  • Cat. No. CS-W022295
  • Purity≥98%
  • MDL No.MFCD05861550

*For research and further manufacturing use only, not for direct human use.

5-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride|CS-W022295

Structure of 923591-51-9

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General Information

  • CAS No. 923591-51-9
  • Cat. No. CS-W022295
  • Purity ≥98%
  • MDL No. MFCD05861550
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁BrClN
  • Molecular Weight 248.55
  • Synonym(s) ISOQUINOLINE, 5-BROMO-1,2,3,4-TETRAHYDRO-, HYDROCHLORIDE
  • SMILES BrC1=CC=CC2=C1CCNC2.Cl

Description

5-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride offers a brominated heterocyclic scaffold with enhanced solubility and stability under standard conditions. This bench-stable salt integrates readily into synthetic workflows, providing a versatile building block for medicinal chemistry and bioactive molecule development.

Application

5-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The bromine substituent at the 5-position provides high reactivity in Suzuki, Stille, and Negishi couplings, while the tetrahydroisoquinoline core offers a rigid, bioactive scaffold relevant to CNS-targeted compounds. The hydrochloride salt enhances solubility and stability, facilitating handling and purification in synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.5166
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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