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CS-W001157 4
Total: USD 88.00

7-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride

  • CAS No. 220247-73-4

  • Cat. No. CS-D1568
  • Purity≥97%
  • MDL No.MFCD03094742

*For research and further manufacturing use only, not for direct human use.

7-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride|CS-D1568

Structure of 220247-73-4

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General Information

  • CAS No. 220247-73-4
  • Cat. No. CS-D1568
  • Purity ≥97%
  • MDL No. MFCD03094742
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁BrClN
  • Molecular Weight 248.55
  • Synonym(s) 7-Bromo-1,2,3,4-tetrahydroisoquinolinehydrochloride
  • SMILES BrC1=CC2=C(C=C1)CCNC2.[H]Cl

Description

7-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride offers a stable, moisture-tolerant platform for medicinal chemistry applications. The bromine substituent at the 7-position enables direct functionalization via cross-coupling reactions. This bench-stable salt form enhances solubility and handling in aqueous-based synthesis workflows.

Application

7-Bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling. Its brominated aromatic ring facilitates Suzuki, Stille, and Negishi reactions, while the protonated tetrahydroisoquinoline core offers enhanced solubility and stability in aqueous/organic media. The salt form improves handling and purification, making it ideal for high-throughput synthesis of bioactive heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.5166
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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