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CS-W001157 4
Total: USD 88.00

4-Bromo-1-methyl-1H-indazole

  • CAS No. 365427-30-1

  • Cat. No. CS-0045009
  • Purity≥98%
  • MDL No.MFCD09870042

*For research and further manufacturing use only, not for direct human use.

4-Bromo-1-methyl-1H-indazole|CS-0045009

Structure of 365427-30-1

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General Information

  • CAS No. 365427-30-1
  • Cat. No. CS-0045009
  • Purity ≥98%
  • MDL No. MFCD09870042
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrN₂
  • Molecular Weight 211.06
  • Synonym(s) 4-Bromo-1-methylindazole
  • SMILES CN1N=CC2=C1C=CC=C2Br

Description

4-Bromo-1-methyl-1H-indazole is a bench-stable heterocyclic scaffold featuring a bromine substituent at the 4-position and a methyl group at nitrogen. This combination enables direct functionalization in cross-coupling reactions and supports integration into bioactive molecules for medicinal chemistry applications.

Application

4-Bromo-1-methyl-1H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo functionality. The methyl-substituted indazole core provides enhanced metabolic stability and favorable pharmacophore properties. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of complex heterocyclic scaffolds for drug discovery applications.

Synthesis

  • Route1
    • In-stock
      2-Bromo-6-fluorobenzaldehyde|CS-D1749
      360575-28-6
    • null|null
      60-34-4
    • ~%
    • In-stock
      4-Bromo-1-methyl-1H-indazole|CS-0045009
      365427-30-1

    References

    • WO2008/24945 A1, ; Page/Page column 29 ; WO 2008/024945 A1
  • Route2

    References

    • Bioorganic and Medicinal Chemistry, , vol. 20, # 17 p. 5296 - 5304
  • Route3

    References

    • US2012/245163 A1, ; US 20120245163 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   2.3358
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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