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CS-W001157 4
Total: USD 88.00

4-(Hydroxymethyl)picolinic acid

  • CAS No. 923169-37-3

  • Cat. No. CS-0100548
  • Purity≥95%
  • MDL No.MFCD08447083

*For research and further manufacturing use only, not for direct human use.

4-(Hydroxymethyl)picolinic acid|CS-0100548

Structure of 923169-37-3

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General Information

  • CAS No. 923169-37-3
  • Cat. No. CS-0100548
  • Purity ≥95%
  • MDL No. MFCD08447083
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₃
  • Molecular Weight 153.14
  • Synonym(s) 4-(Hydroxymethyl)pyridine-2-ca
  • SMILES O=C(C1=NC=CC(CO)=C1)O

Description

4-(Hydroxymethyl)picolinic acid features a pyridine ring bearing both a carboxylic acid and a hydroxymethyl group at the para position, enabling versatile conjugation chemistry. This configuration supports efficient coupling to biomolecules via amine-reactive esters or metal chelation through the pyridine nitrogen and carboxylate. The hydroxymethyl moiety provides a handle for further functionalization, enhancing utility in probe design and drug delivery systems.

Application

4-(Hydroxymethyl)picolinic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation of both carboxylic acid and hydroxymethyl functionalities for downstream derivatization. Its stability under standard reaction conditions facilitates efficient conjugation, esterification, or oxidation to aldehyde, supporting diverse synthetic routes in API development and heterocyclic scaffold construction.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.42
  • LogP   0.2721
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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