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CS-W001157 4
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5-Phenyl-1H-pyrazol-4-amine

  • CAS No. 91857-86-2

  • Cat. No. CS-0156351
  • Purity≥95%
  • MDL No.MFCD01693716

*For research and further manufacturing use only, not for direct human use.

5-Phenyl-1H-pyrazol-4-amine|CS-0156351

Structure of 91857-86-2

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General Information

  • CAS No. 91857-86-2
  • Cat. No. CS-0156351
  • Purity ≥95%
  • MDL No. MFCD01693716
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉N₃
  • Molecular Weight 159.19
  • Synonym(s) 5-phenyl-1H-pyrazol-4-amine 2HCl H2O
  • SMILES C1=CC=C(C=C1)C2=NNC=C2N

Description

5-Phenyl-1H-pyrazol-4-amine features a conjugated pyrazole core bearing a phenyl substituent at the 5-position and an amine group at the 4-position, enabling integration into diverse heterocyclic scaffolds. This electron-rich architecture supports efficient coupling reactions and facilitates incorporation into bioactive molecules for medicinal chemistry applications.

Application

5-Phenyl-1H-pyrazol-4-amine serves as a versatile scaffold in medicinal chemistry, enabling rapid access to bioactive heterocycles through standard functionalization at the 4-amino and 5-phenyl positions. Its bench-stable nature and compatibility with Suzuki, Buchwald-Hartwig, and electrophilic substitution reactions facilitate efficient diversification for drug discovery campaigns.

Synthesis

  • Route1

    References

    • Wilcoxen, Keith; Huang, Charles Q.; McCarthy, James R.; Grigoriadis, Dimitri E.; Chen, Chen Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 19 p. 3367 - 3370
  • Route2
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      30159-39-8
    • ~%
    • In-stock
      5-Phenyl-1H-pyrazol-4-amine|CS-0156351
      91857-86-2

    References

    • Kishimoto; Noguchi; Masuda Chemical and Pharmaceutical Bulletin, 1976 , vol. 24, # 12 p. 3001 - 3010
  • Route3
    • null|null
      536-74-3
    • ~%
    • In-stock
      5-Phenyl-1H-pyrazol-4-amine|CS-0156351
      91857-86-2

    References

    • Kishimoto; Noguchi; Masuda Chemical and Pharmaceutical Bulletin, 1976 , vol. 24, # 12 p. 3001 - 3010

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317-H319
Precautionary Statements : P261-P264-P272-P280-P302+P352-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.6589
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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