Tert-butyl methyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate

Name: Tert-butyl methyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 916587-44-5
Cat. No. CS-0174617
Purity≥95%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Tert-butyl methyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate|CS-0174617

Structure of 916587-44-5

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 916587-44-5
Cat. No. CS-0174617
Purity ≥95%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₈H₂₈BNO₄
Molecular Weight 333.23
Synonym(s) t-Butyl-n-methyl-n-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate
SMILES CC(C)(OC(N(C1=CC=C(B2OC(C)(C(C)(O2)C)C)C=C1)C)=O)C

Description

Tert-butyl methyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate features a boronate ester group flanked by a sterically hindered tert-butyl carbamate and methyl substituent. This bench-stable reagent integrates readily into Suzuki-Miyaura coupling reactions under standard conditions, enabling efficient construction of biaryl architectures with minimal protodeboronation.

Application

Tert-butyl methyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate serves as a stable, bench-ready boron building block for Suzuki-Miyaura cross-coupling reactions. The tert-butyl carbamate (Boc) group provides excellent protection for primary amines, enabling orthogonal functionalization in complex molecule synthesis. Its tetramethylborolane moiety ensures high reactivity under standard coupling conditions, with broad functional group tolerance and ease of purification. This reagent facilitates efficient construction of biaryl scaffolds and is well-suited for iterative synthetic strategies in medicinal chemistry and process development.

Synthesis

Route1
- In-stock
  
  330793-01-6
- 74-88-4
- ~72%
- In-stock
  
  916587-44-5
References
- Taisho Pharmaceutical Co., Ltd.; Toyama Chemical Co., Ltd.; TAKASHIMA, Hajime; TSURUTA, Risa; YABUUCHI, Tetsuya; OKA, Yusuke; URABE, Hiroki; SUGA, Yoichiro; TAKAHASHI, Masato; UNEUCHI, Fumito; KOTSUBO, Hironori; SHOJI, Muneo; KAWAGUCHI, Yasuko Patent: EP2562155 A1, 2013 ; Location in patent: Paragraph 0222-0223 ;
Route2
- In-stock
  
  73183-34-3
- In-stock
  
  306768-12-7
- ~64%
- In-stock
  
  916587-44-5
References
- Lin, Chen; Drueckhammer, Dale G. New Journal of Chemistry, 2006 , vol. 30, # 12 p. 1725 - 1730
Route3
- In-stock
  
  24424-99-5
- ~%
- In-stock
  
  916587-44-5
References
- New Journal of Chemistry, , vol. 30, # 12 p. 1725 - 1730

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H317-H413
Precautionary Statements : P261-P272-P273-P280-P302+P352-P363-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 48
LogP 3.3571
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Boronic Acid And Its Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

916587-44-5 sigma916587-44-5 manufacturer916587-44-5 price916587-44-5 structure916587-44-5 SDSbuy 916587-44-5916587-44-5 supplier916587-44-5 uses916587-44-5 molecular weightprice of 916587-44-5916587-44-5 chemical name formula of 916587-44-5

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Tert-butyl methyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate

CAS No. 916587-44-5

Recommended Products

General Information

Description

Application

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words