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CS-W001157 4
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Methyl 2-(chloromethyl)thiazole-4-carboxylate

  • CAS No. 321371-29-3

  • Cat. No. CS-W022793
  • Purity≥98%
  • MDL No.MFCD08669440

*For research and further manufacturing use only, not for direct human use.

Methyl 2-(chloromethyl)thiazole-4-carboxylate|CS-W022793

Structure of 321371-29-3

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General Information

  • CAS No. 321371-29-3
  • Cat. No. CS-W022793
  • Purity ≥98%
  • MDL No. MFCD08669440
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClNO₂S
  • Molecular Weight 191.64
  • Synonym(s) 4-Thiazolecarboxylicacid,2-(chloromethyl)-,methylester(9CI)
  • SMILES ClCC1=NC(=CS1)C(=O)OC

Description

Methyl 2-(chloromethyl)thiazole-4-carboxylate features a reactive chloromethyl group flanked by a thiazole ring and ester functionality, enabling direct functionalization in synthetic sequences. This bench-stable reagent integrates readily into heterocyclic scaffolds under mild conditions, serving as a key intermediate for medicinal chemistry and materials science applications.

Application

Methyl 2-(chloromethyl)thiazole-4-carboxylate serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of thiazole-based scaffolds. The chloromethyl group facilitates nucleophilic substitution reactions, while the ester functionality supports further transformations such as hydrolysis or reduction. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for medicinal chemistry campaigns and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.6685
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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