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Structure of 91658-92-3
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2-Fluoro-3-hydroxybenzoic acid features a strategically positioned fluorine atom and hydroxyl group on the aromatic ring, enabling enhanced electronic modulation and hydrogen bonding potential. This combination supports efficient incorporation into bioactive scaffolds and facilitates downstream functionalization in medicinal chemistry campaigns under standard conditions.
2-Fluoro-3-hydroxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the ortho-fluorine position via nucleophilic substitution. The adjacent hydroxyl and carboxylic acid groups provide orthogonal handles for derivatization, including esterification, amide coupling, or protection strategies. Its stability under standard bench conditions and compatibility with common reaction protocols make it well-suited for the synthesis of bioactive heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: