Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

  • CAS No. 91526-18-0

  • Cat. No. CS-W004926
  • Purity≥95%
  • MDL No.MFCD12165896

*For research and further manufacturing use only, not for direct human use.

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one|CS-W004926

Structure of 91526-18-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 91526-18-0
  • Cat. No. CS-W004926
  • Purity ≥95%
  • MDL No. MFCD12165896
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆O₄
  • Molecular Weight 130.10
  • Synonym(s) 4-hydroxymethyl-5-methyl-1,3-dioxol-2-one
  • SMILES CC1=C(CO)OC(=O)O1

Description

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a bench-stable, moisture-tolerant synthon featuring a reactive α-hydroxycarbonyl moiety. This structure integrates readily into cascade cyclizations and C–C bond-forming sequences, enabling efficient access to functionalized heterocycles under mild conditions.

Application

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one serves as a versatile synthon in medicinal chemistry, enabling efficient access to functionalized heterocyclic scaffolds. Its α,β-unsaturated γ-lactone core facilitates Michael additions and nucleophilic transformations under mild conditions. The hydroxymethyl group provides a handle for further derivatization, while the molecule exhibits good bench stability and compatibility with common protecting group strategies. This compound functions effectively in multi-step synthesis workflows requiring controlled reactivity and predictable regioselectivity.

Synthesis

  • Route1

    References

    • US6054587 A1, ; US 6054587 A
  • Route2

    References

    • JUBILANT LIFE SCIENCES LIMITED; BANSAL, Deepak; MISHRA, Himanchal; DUBEY, Shailendr, Kumar; CHOUDHARY, Alka, Srivastava; VIR, Dharam; AGARWAL, Ashutosh Patent: WO2012/107814 A1, 2012 ; Location in patent: Page/Page column 14-15 ;
  • Route3
    • null|null
      91526-17-9
    • ~%
    • In-stock
      4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one|CS-W004926
      91526-18-0

    References

    • Synthetic Communications, , vol. 22, # 9 p. 1277 - 1282

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   63.58
  • LogP   0.03352
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 91526-18-0 sigma91526-18-0 manufacturer91526-18-0 price91526-18-0 structure91526-18-0 SDSbuy 91526-18-091526-18-0 supplier91526-18-0 uses91526-18-0 molecular weightprice of 91526-18-091526-18-0 chemical name formula of 91526-18-0
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label