Methyl 6-chloro-5-hydroxynicotinate

Name: Methyl 6-chloro-5-hydroxynicotinate
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CAS No. 915107-30-1
Cat. No. CS-0037678
Molecule weight187.58
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Methyl 6-chloro-5-hydroxynicotinate|CS-0037678

Structure of 915107-30-1

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General Information

CAS No. 915107-30-1
Cat. No. CS-0037678
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆ClNO₃
Molecular Weight 187.58
Synonym(s) METHYLl 6-CHLORO-5-HYDROXYNICOTINATE
SMILES O=C(C1=CC(O)=C(Cl)N=C1)OC

Description

Methyl 6-chloro-5-hydroxynicotinate features a strategically positioned hydroxyl group and chloro substituent on the pyridine ring, enabling selective functionalization in medicinal chemistry. This bench-stable derivative integrates readily into synthetic routes requiring electron-deficient heterocyclic scaffolds.

Application

Methyl 6-chloro-5-hydroxynicotinate serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds. The pendant hydroxyl group facilitates direct derivatization via esterification, etherification, or oxidation, while the chloro substituent supports palladium-catalyzed cross-coupling reactions. Its bench-stable nature and compatibility with common protecting group strategies streamline synthesis workflows for heterocyclic compounds and API intermediates.

Synthesis

Route1
- In-stock
  
  30766-22-4
- ~41%
- In-stock
  
  915107-30-1
References
- Zhu, Yuanming; Loso, Michael R.; Nugent, Benjamin M.; Huang, Jim X.; Rogers, Richard B. Patent: US2008/108667 A1, 2008 ; Location in patent: Page/Page column 9-10 ;
Route2
- 100-39-0
- In-stock
  
  30766-22-4
- ~%
- In-stock
  
  915107-30-1
References
- Pfefferkorn, Jeffrey A.; Tu, Meihua; Filipski, Kevin J.; Guzman-Perez, Angel; Bian, Jianwei; Aspnes, Gary E.; Sammons, Matthew F.; Song, Wei; Li, Jian-Cheng; Jones, Christopher S.; Patel, Leena; Rasmusson, Tim; Zeng, Dongxiang; Karki, Kapil; Hamilton, Michael; Hank, Richard; Atkinson, Karen; Litchfield, John; Aiello, Robert; Baker, Levenia; Barucci, Nicole; Bourassa, Patricia; Bourbounais, Francis; D'Aquila, Theresa; Derksen, David R.; MacDougall, Margit; Robertson, Alan Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7100 - 7105

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 59.42
LogP 1.2272
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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Methyl 6-chloro-5-hydroxynicotinate

CAS No. 915107-30-1

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