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CS-W001157 4
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Methyl 5-hydroxynicotinate

  • CAS No. 30766-22-4

  • Cat. No. CS-W001532
  • Purity≥97%
  • MDL No.MFCD00191521

*For research and further manufacturing use only, not for direct human use.

Methyl 5-hydroxynicotinate|CS-W001532

Structure of 30766-22-4

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General Information

  • CAS No. 30766-22-4
  • Cat. No. CS-W001532
  • Purity ≥97%
  • MDL No. MFCD00191521
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₃
  • Molecular Weight 153.14
  • Synonym(s) methyl 5-hydroxypyridine-3-carboxylate
  • SMILES COC(=O)c1cncc(c1)O

Description

Methyl 5-hydroxynicotinate features a pyridine ring bearing both methyl ester and hydroxyl substituents at the 5-position, enabling dual functionalization in synthetic sequences. This bench-stable derivative serves as a key intermediate for bioactive heterocycles and pharmaceutical precursors.

Application

Methyl 5-hydroxynicotinate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized pyridine derivatives. The molecule combines a hydroxyl group at the C5 position with a methyl ester, offering orthogonal reactivity for selective transformations. It functions effectively in coupling reactions, oxidation processes, and heterocycle elaboration, demonstrating bench stability and compatibility with standard purification methods.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      5-Hydroxynicotinic acid|CS-W009148
      27828-71-3
    • ~80%
    • In-stock
      Methyl 5-hydroxynicotinate|CS-W001532
      30766-22-4

    References

    • WO2008/154563 A1, ; Page/Page column 91-92 ; WO 2008/154563 A1
  • Route2
    • null|null
      958266-11-0
    • ~75%
    • In-stock
      Methyl 5-hydroxynicotinate|CS-W001532
      30766-22-4

    References

    • European Journal of Organic Chemistry, , # 26 p. 4408 - 4430
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 10 p. 3095 - 3098

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   0.5738
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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