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5-Hydroxynicotinaldehyde

  • CAS No. 1060804-48-9

  • Cat. No. CS-0063897
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Hydroxynicotinaldehyde|CS-0063897

Structure of 1060804-48-9

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General Information

  • CAS No. 1060804-48-9
  • Cat. No. CS-0063897
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅NO₂
  • Molecular Weight 123.11
  • Synonym(s) 5-Hydroxypyridine-3-carboxaldehyde, 3-Formyl-5-hydroxypyridine
  • SMILES O=CC1=CC(O)=CN=C1

Description

5-Hydroxynicotinaldehyde features a strategically positioned hydroxyl group adjacent to the aldehyde functionality, enabling direct participation in hydrogen bonding and facilitating nucleophilic addition reactions. This electron-deficient heteroaromatic scaffold integrates readily into bioactive molecule synthesis, offering enhanced solubility and reactivity under standard conditions.

Application

5-Hydroxynicotinaldehyde serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling direct access to functionalized heterocycles. Its dual aldehyde and phenolic hydroxyl groups offer orthogonal reactivity for coupling, cyclization, and derivatization under mild conditions. The compound exhibits good bench stability and facilitates efficient purification, making it suitable for use in multi-step syntheses of bioactive scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   0.5997
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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