Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

5-Hydroxynicotinic acid

  • CAS No. 27828-71-3

  • Cat. No. CS-W009148
  • Purity≥96%
  • MDL No.MFCD00129117

*For research and further manufacturing use only, not for direct human use.

5-Hydroxynicotinic acid|CS-W009148

Structure of 27828-71-3

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 27828-71-3
  • Cat. No. CS-W009148
  • Purity ≥96%
  • MDL No. MFCD00129117
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅NO₃
  • Molecular Weight 139.11
  • Synonym(s) 5-Hydroxynicotinic acid; 5-Hydroxypyridine-3-carboxylic acid; NSC 606891; 5-hydroxypyridine-3-carboxylate
  • SMILES O=C(C1=CC(O)=CN=C1)O

Description

5-Hydroxynicotinic acid is a bench-stable, electron-deficient heterocycle bearing a carboxylic acid and phenolic hydroxyl group at adjacent positions on the pyridine ring. This dual functionality enables direct coupling in peptide synthesis and facilitates metal chelation for catalytic applications. The molecule integrates readily into bioactive scaffolds requiring hydrogen-bonding motifs or redox-active centers.

Application

5-Hydroxynicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds and bioactive molecules through established coupling and cyclization protocols. Its ortho-hydroxy group facilitates chelation and enhances solubility, while the carboxylic acid functionality supports direct derivatization or activation for amide bond formation. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows.

Synthesis

  • Route1
    • 5-Bromonicotinic acid Nicergoline Impurity|CS-0492508
      20826-04-4
    • ~60%
    • In-stock
      5-Hydroxynicotinic acid|CS-W009148
      27828-71-3

    References

    • INSA ROUEN; GOUS INC. Patent: WO2006/103120 A2, 2006 ; Location in patent: Page/Page column 115 ; WO 2006/103120 A2
  • Route2

    References

    • Graf Journal fuer Praktische Chemie (Leipzig), 1933 , vol. <2> 138, p. 244,257
  • Route3

    References

    • Jacobsen; Labouta; Schaumburg; Falch; Krogsgaard-Larsen Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1157 - 1162

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   70.42
  • LogP   0.4854
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 5-Hydroxynicotinic acid sigma5-Hydroxynicotinic acid manufacturer5-Hydroxynicotinic acid price5-Hydroxynicotinic acid structure5-Hydroxynicotinic acid SDSbuy 5-Hydroxynicotinic acid5-Hydroxynicotinic acid supplier5-Hydroxynicotinic acid uses5-Hydroxynicotinic acid molecular weightprice of 5-Hydroxynicotinic acid5-Hydroxynicotinic acid chemical name formula of 5-Hydroxynicotinic acid
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label