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CS-W001157 4
Total: USD 88.00

5,6,7,8-Tetrahydro-imidazo[1,2-a]pyrazine

  • CAS No. 91476-80-1

  • Cat. No. CS-W019673
  • Purity≥95%
  • MDL No.MFCD09701264

*For research and further manufacturing use only, not for direct human use.

5,6,7,8-Tetrahydro-imidazo[1,2-a]pyrazine|CS-W019673

Structure of 91476-80-1

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General Information

  • CAS No. 91476-80-1
  • Cat. No. CS-W019673
  • Purity ≥95%
  • MDL No. MFCD09701264
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃
  • Molecular Weight 123.16
  • Synonym(s) 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine
  • SMILES C12=NC=CN1CCNC2

Description

5,6,7,8-Tetrahydro-imidazo[1,2-a]pyrazine is a saturated heterocyclic scaffold featuring fused imidazole and pyrazine rings. This rigid, electron-rich core exhibits enhanced stability and favorable solubility in polar solvents, enabling efficient integration into medicinal chemistry libraries. Its well-defined geometry supports precise molecular positioning in target-directed compound design.

Application

5,6,7,8-Tetrahydro-imidazo[1,2-a]pyrazine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard functionalization and coupling reactions. Its saturated core offers enhanced metabolic stability and favorable physicochemical properties, while maintaining compatibility with common synthetic transformations. The scaffold functions as a privileged template in CNS-targeted compound discovery and demonstrates robust bench stability for routine handling and purification.

Synthesis

  • Route1

    References

    • Bonnet, Pierre-Antoine; Sablayrolles, Claire; Chapat, Jean-Pierre Journal of Chemical Research, Miniprint, 1984 , # 2 p. 468 - 480
  • Route2
    • 7-Benzyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine|CS-1716768
      1351991-50-8
    • ~%
    • In-stock
      5,6,7,8-Tetrahydro-imidazo[1,2-a]pyrazine|CS-W019673
      91476-80-1

    References

    • US2011/301170 A1, ; Page/Page column 24 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.85
  • LogP   -0.0137
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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